Evaluarea efectului combinat al multiplelor polimorfisme pentru a defini predispoziția genetică în neoplasmele mieloproliferative, Cod PN-III-P1-1.1-PD-2016-1414.

Pre Proposal Registration Code	PD-2016-1474
Project Registration Code	Assessing the combined effect of multiple polymorphisms in order to define the genetic predisposition to myeloproliferative neoplasms
Project Acronym	POLYMYEL
Purpose and project planning	PN-III-P1-1.1-PD-2016-1414
Project Start Date	2 may 2018
Project End Date	30 apirlie 2020
Project Duration	24 months
Main objectives	The major objective of the project is to assess the independent and combined effect of a large panel of genetic polymorphisms in the occurrence of non-BCR-ABL myeloproliferative neoplasms and chronic myeloid leukemia and the dynamic of somatic mutations specific to these diseases (eg JAK2 V617F, CALR, BCR-ABL), in order to generate a complex mathematical model of genetic predisposition to these diseases.
Team:	TRIFA ADRIAN PAVEL -> PROJECT LEADER BANESCU CLAUDIA VIOLETA -> MENTOR
Results	Validation of the genotyping protocols for the genetic polymorphisms that are to be analyzed in patients with non-BCR-ABL myeloproliferative neoplasms, chronic myeloid leukemia, and controls. – Distribution of genotypes and alleles for the genetic polymorphisms that are to be analyzed in patients with non-BCR-ABL myeloproliferative neoplasms, chronic myeloid leukemia, and controls. – A mathematical model regarding the genetic predisposition to these diseases. – An Original article published in a prestigious journal of hematology; – Oral presentations or posters at national and international conferences
Host institution	University of Medicine and Pharmacy of Tirgu Mures